During sexual intercourse, serotonin is one of the central regulators of the ejaculatory reflex. Dapoxetine increases its concentration in the synaptic cleft (pathway of mediators), inhibiting the reuptake of receptors. The result is a slight antidepressant effect and an increase in the time to ejaculation.
Method of administration and recommended dosages
Priligy is available in blue or gray-green tablets with a biconvex shape. The drug is taken orally regardless of the meal. The concentration of the drug in the blood plasma reaches a maximum level after an hour and a half, so it is necessary to take Priligy 1-3 hours before the planned sexual contact.
The recommended initial dose for men is 30 mg. If the desired effect is not achieved, it is acceptable to double the dose. The frequency of taking the drug Priligy, should not exceed more that one time per day.
Priligy has a number of restrictions for concurrent use with certain drugs. Such drugs as tramadol, lithium, and norepinephrine reuptake inhibitors require 14-day pause before starting to take Priligy.
Simultaneous administration with ketoconazole, ritonavir, atazanavir, saquinavir is prohibited. Concomitant use with anticoagulants increases the risk of bleeding. Priligy should be used with caution in conjunction with phosphodiesterase inhibitors because such co-administration can lead to lower blood pressure. Dapoxetine has no clinically important interactions with Cialis (tadalafil) or Viagra (sildenafil) and the combinations are well tolerated.
Dosage: 30mg / 60mg tablets
Online Price: $0.95 – $4 per pill
Active Ingredient: Dapoxetine hydrochloride
Duration: 6-8 hours
Admission: 1-2 hours before sexual intercourse
Company: Menarini Group
Treatment for: Premature Ejaculation
Recommended daily dose: 60 mg
Treatment with dapoxetine-based drugs can cause adverse reactions, the manifestation of which depends on the dose taken and individual tolerance. Anxiety, depression, apathy is possible to occur. Sometimes there may be mood changes, sleep disturbances and irritability.
The central nervous system can respond with headache, drowsiness, and distraction of attention. In some cases, the use of Priligy may cause tachycardia and lower blood pressure. Some patients noted nasal congestion, diarrhea, abdominal tenderness. An increase in blood pressure and heart rate is also not excluded.